Eddie A James Selected Research

Insulin (Novolin)

1/2024	An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes.
12/2023	The beta cell-immune cell interface in type 1 diabetes (T1D).
1/2023	Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes.
1/2022	Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity.
1/2021	Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide.
1/2020	Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01.
1/2020	T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal.
1/2020	Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.
12/2019	A composite immune signature parallels disease progression across T1D subjects.
1/2018	Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

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Eddie A James Research Topics

Disease

37	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2024 - 03/2006
19	Rheumatoid Arthritis 11/2023 - 10/2010
11	Human Influenza (Influenza) 07/2023 - 07/2006
8	Autoimmune Diseases (Autoimmune Disease) 12/2023 - 02/2012
7	Inflammation (Inflammations) 03/2024 - 03/2014
4	Infections 03/2024 - 01/2016
4	Hemophilia A (Haemophilia) 01/2018 - 08/2009
4	Multiple Sclerosis 01/2017 - 01/2015
4	Hypersensitivity (Allergy) 03/2014 - 05/2011
3	Arthritis (Polyarthritis) 11/2023 - 10/2016
3	Disease Progression 07/2023 - 01/2020
3	Celiac Disease (Celiac Sprue) 11/2015 - 09/2014
2	Hyperglycemia 01/2022 - 01/2015
2	Yellow Fever 01/2020 - 12/2013
2	Peanut Hypersensitivity (Peanut Allergy) 01/2018 - 05/2011
2	Seasonal Allergic Rhinitis (Hay Fever) 03/2014 - 02/2012
1	Gastritis 03/2024
1	Synovitis 01/2023
1	Dysbiosis 09/2022
1	Vasculitis (Vasculitides) 01/2022
1	Myositis (Idiopathic Inflammatory Myopathies) 01/2020
1	Crohn Disease (Crohn's Disease) 01/2020
1	Antisynthetase syndrome 01/2020
1	Retinoblastoma (Glioblastoma, Retinal) 10/2019
1	Neoplasms (Cancer) 10/2019
1	Skin Neoplasms (Skin Cancer) 10/2019
1	Merkel Cell Carcinoma 10/2019
1	Epstein-Barr Virus Infections 01/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2018
1	Atherosclerosis 11/2018

Drug/Important Bio-Agent (IBA)

29	EpitopesIBA 07/2023 - 07/2006
28	Peptides (Polypeptides)IBA 02/2024 - 05/2008
23	Proteins (Proteins, Gene)FDA Link 02/2024 - 03/2006
23	AntigensIBA 11/2023 - 07/2006
12	Insulin (Novolin)FDA Link 01/2024 - 10/2014
11	AutoantigensIBA 07/2023 - 03/2006
10	AutoantibodiesIBA 01/2023 - 10/2016
8	AntibodiesIBA 03/2024 - 12/2013
7	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2022 - 12/2013
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2011
6	HLA-DR Antigens (HLA-DR)IBA 01/2022 - 08/2011
5	HLA Antigens (Human Leukocyte Antigens)IBA 12/2023 - 01/2017
4	CytokinesIBA 01/2022 - 06/2011
4	HLA-DRB1*04:01 antigenIBA 10/2019 - 01/2016
4	AllergensIBA 01/2018 - 02/2012
4	Factor VIII (Coagulation Factor VIII)IBA 01/2018 - 08/2009
3	HLA-DRB1 Chains (HLA DRB1)IBA 01/2022 - 10/2010
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2020 - 12/2013
3	VaccinesIBA 10/2019 - 02/2012
3	Phosphopyruvate Hydratase (Enolase)IBA 01/2019 - 01/2016
3	Neutralizing AntibodiesIBA 01/2018 - 08/2009
2	Immunoglobulin A (IgA)IBA 03/2024 - 10/2022
2	C-PeptideIBA 01/2024 - 01/2020
2	Immunodominant EpitopesIBA 07/2023 - 01/2018
2	HLA-DR alpha-ChainsIBA 07/2023 - 08/2009
2	Immunoglobulin G (IgG)IBA 10/2022 - 11/2021
2	ProinsulinIBA 01/2022 - 12/2018
2	Hemagglutinins (Hemagglutinin)IBA 01/2020 - 07/2006
2	HLA-DQ8 antigenIBA 01/2019 - 01/2014
2	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2018 - 01/2018
1	Cytotoxins (Cytolysins)IBA 03/2024
1	Chromogranin AIBA 01/2024
1	Chemotactic FactorsIBA 12/2023
1	preproinsulinIBA 07/2023
1	Messenger RNA (mRNA)IBA 01/2023
1	Hydroxyl RadicalIBA 01/2023
1	Rheumatoid FactorIBA 09/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Amino Acids FDA Link 01/2022
1	Myeloblastin (Proteinase 3)IBA 01/2022
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2022
1	GlucokinaseIBA 01/2022
1	HLA-DPB1 antigen (HLA DPB1)IBA 01/2022
1	TenascinIBA 01/2021
1	Extracellular Matrix ProteinsIBA 01/2021
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Interleukin-2 (IL2)IBA 01/2020
1	InterferonsIBA 01/2020
1	Chemokine ReceptorsIBA 01/2020
1	CD40 Ligand (CD40L)IBA 01/2020
1	Bacterial AntigensIBA 01/2020
1	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2020
1	IntegrinsIBA 01/2020
1	Oncogene Proteins (Oncogene Protein)IBA 10/2019
1	VimentinIBA 01/2019
1	HLA-DQA1 antigen (HLA DQA1)IBA 01/2019
1	Aggrecans (Aggrecan)IBA 01/2019
1	Fibrinogen (Factor I)FDA Link 01/2019
1	Endoplasmic Reticulum Chaperone BiPIBA 11/2018
1	Apolipoproteins B (ApoB)IBA 11/2018
1	Glucose (Dextrose)FDA LinkGeneric 11/2018
1	Transcription Factors (Transcription Factor)IBA 11/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 11/2018
1	Immunoglobulin E (IgE)IBA 01/2018
1	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2018
1	EnzymesIBA 01/2018
1	CalciumIBA 01/2018

Therapy/Procedure

5	Therapeutics 07/2023 - 08/2009
3	Immunotherapy 03/2014 - 05/2011